engleski

Lung function measurement and exhaled nitric oxide in children with allergic rhinitis

Allergic rhinitis can often lead to asthma. it is known that some inflammatory markers are in common for both diseasees.Aim of our study was to evaluate lung function measurements and level ofexhaled NO(eNO) in patients with allergic rhinitisa. Subject and metods: In a group of 53 children (35 male, 4-18 yrs, without initial therapy) with diagnosed allergic rhinitis without asthma we measured lung function, eNO, evaluated allergen sensitivty (skin prick test, specific IgE)and therapy and compared them to the 37 health controls (22 male, 4-18 yrs) for lung function measures.Resalts: Fifty one percent of patients were allergic to pollen, 9 to mites, 2 to other perennial allergens and pollen, 23 to pollen and mites, and 15 were multisensitized. Spirometry showed lower values in 15% patients and 5% controls(FVC<80% predicted), while up to 19% (none in controls) had lower values in the area of small airways (MEF25 or MEF50<80%), and up to 28% (21%in controls)in the area of large airways (MEF75 or PEF<80%).53% of patients (27% in controls) had any of lung function measures "impaired". In 17% of patients we found elevated eNO levels(diagnostic for asthma).We didn't find any association between type of allergen and lung function measurements or measured eNO levels. After initial therapy was introduced we found no improvement in lung function measurements.Conclusion: It seems that allergic rhinitis in children can be related to lower values of lung function measures with clinical symptoms.AS these children may have increased risk for asthma they deserve further monitoring.

allergic rhinitis; inflammatory markers

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