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Perforin mediated natural killer cytotoxicity (CROSBI ID 464050)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Balen-Marunić, Sanja ; Rukavina, Daniel Perforin mediated natural killer cytotoxicity // Life Sciences / Eržen, (ur.). Ljubljana: Society for stereology and quantitative image analysis, 1996. str. 99-101-x

Podaci o odgovornosti

Balen-Marunić, Sanja ; Rukavina, Daniel

engleski

Perforin mediated natural killer cytotoxicity

Cytotoxic lymphocytes are endowed with potent cytolytic machinery located in the cytoplasmic granules and containing cytolytic molecule perforin (pore forming protein) and associated granule proteases (granzymes). Perforin and granzymes are responsible for enforced death of noncooperative targets, whereas Fas and Fas ligand are responsible for induced suicide of compliant cells (perforin independent surface-receptor mediated pathway). Enforced cell death is critical for the elimination of parasitised cells. In unstimulated PBL perforin mRNA and protein is constitutively expressed in NK (high level of expression) and in the subpopulation of CD8+ cells expressing CD11b antigen (moderate expression). However perforin can be induced in CD8+CD11b- subpopulation and in some CD4+ lymphocytes. Perforin is constitutively expressed also in CD3+CD4-CD8- gama/deltaTCR subpopulation of PBL, but can be found also in CD3+CD4-CD8- alphabetaTCR+ subpopulation. Normal noninfected tissues are almost completely free of perforin+ cells. However, during pregnancy perforin+ cells appear abundantly in the granulated metrial gland (GMG) cells of the pregnancy in quantities higher than in any pathological condition.

perforin; NK cells; cell mediated cytotoxicity

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Podaci o prilogu

99-101-x.

1996.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Life Sciences

Eržen,

Ljubljana: Society for stereology and quantitative image analysis

Podaci o skupu

3rd International Conference Life Sciences

ostalo

21.09.1996-26.09.1996

Gozd Martuljek, Slovenija

Povezanost rada

Kliničke medicinske znanosti