Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Complex of Burkholderia cepacia lipase with transition state analogue of 1-phenoxy-2-acetoxybutane, Biocatalytic, structural and modelling study. (CROSBI ID 86969)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Luić, Marija ; Tomić, Sanja ; Leščić, Ivana ; Ljubović, Edina ; Šepac, Dragan ; Šunjić, Vitomir ; Vitale, Ljubinka ; Saenger, Wolfram ; Kojić-Prodić, Biserka Complex of Burkholderia cepacia lipase with transition state analogue of 1-phenoxy-2-acetoxybutane, Biocatalytic, structural and modelling study. // European journal of biochemistry, 268 (2001), 14; 3964-3973-x

Podaci o odgovornosti

Luić, Marija ; Tomić, Sanja ; Leščić, Ivana ; Ljubović, Edina ; Šepac, Dragan ; Šunjić, Vitomir ; Vitale, Ljubinka ; Saenger, Wolfram ; Kojić-Prodić, Biserka

engleski

Complex of Burkholderia cepacia lipase with transition state analogue of 1-phenoxy-2-acetoxybutane, Biocatalytic, structural and modelling study.

In a series of four racemic phenoxyalkyl-alkyl carbinols, 1-phenoxy-2-hydroxy butane (1) is enantioselectively acetylated by Burkholderia cepacia (formerly Pseudomonas cepacia) lipase with an E-value >200, whereas for the other three racemates E was found to be <4. To explain the high preference of B. cepacia lipase for (R)-(+)-1, a precursor of its transition state analogue with a tetrahedral P-atom, (RP,SP)-methyl-O-(2R)-1-phenoxybut-2-yl) phosphonic acid chloride was prepared and crystallised in complex with B. cepacia lipase. The X-ray structure of the complex was determined, allowing to compare the conformation of the inhibitor with results of molecular modelling.

Burkholderia cepacia lipase; Pseudomonas cepacia lipase; racemic sec alcohols; transition state (TS) analogue; crystal structure; molecular modelling

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

268 (14)

2001.

3964-3973-x

objavljeno

0014-2956

Povezanost rada

Kemija

Indeksiranost