Human decidualized endometrial T lymphocytes express reduced levels of cytoplasmic CD3zeta (CROSBI ID 464052)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Bedenicki, Ivica ; Christmas, Stephen E. ; Newton, Darren J. ; Flanagan, Brian F. ; Rukavina, Daniel ; Johnson, Peter M.
engleski
Human decidualized endometrial T lymphocytes express reduced levels of cytoplasmic CD3zeta
T lymphocytes comprise 5-10% of leukocytes in the human decidualized endometrium in pregnancy. The immunobiological function of these cells is unknown, but their T cell antigen receptor (TCR) has been reported to be downregulated in pregnancy. We have analyzed expression of cell cytoplasmic CD3zeta, a component of the TCR complex involved in intracellular signalling, in human first trimester decidual T cells using flow cytometric analysis of permeabilized cells. A mean of 75% of decidual T cells co-expressed cytoplasmic CD3zeta and cell surface CD3eta, which was not different from peripheral blood T cells (p<0.1). However, the levels of CD3zeta expression were significantly lower in decidual than peripheral T cells, assessed by mean fluorescence intensity (4.2 vs. 5.5 ; p<0.05), in the presence of higher levels of cell surface CD3eta (10.1 vs. 6.6 ; p<0.05). CD3zeta was not systemically downregulated since cytoplasmic CD3zeta levels did not differ significantly in peripheral blood T cells from pregnant women compared with non-pregnant controls (p<0.2). CD8+ T cells outnumber CD4+ T cells in decidua but the proportions of these two T cell subsets that expressed cytoplasmic CD3zeta were not significantly different. These results demonstrate that human decidual T cells locally downregulate CD3zeta, which may compromise their capacity for activation.
T lymphocytes; CD3 zeta; decidual lymphocytes
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Podaci o prilogu
54-54-x.
1997.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Journal of Reproductive Immunology 34 (1997), 1
Bilington, W.D. ; Johnson, P.M. ; Scott, J.R.
Charlottesville (VA): Elsevier
Podaci o skupu
First International Conference on Experimental and Clinical Reproductive Immunobiology
predavanje
30.09.1997-03.10.1997
Charlottesville (VA), Sjedinjene Američke Države