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Genotoxic effect of quercetin/lanthnum complex on human cervical carcinoma cells

Quercetin is the main flavonoid present in our diet. Because of its specific chemical and biological properties, quercetin has been one of the most studied flavonoids for potential cardiovascular, neurodegenerative diseases and cancer treatments. Quercetin readily forms chelates with metal ions as a result of specific chemical structure. The aim of this study was to evaluate potential genotoxic effect of quercetin/lanthanum complex on human cervical carcinoma cells. First the influence of physiological solution on cells viability was investigated due to it's instability in physiological conditions and stability in isotonic solution of sodium chloride. Investigated complex showed considerable cytotoxicity within 100-1000 μ M concentration during 3 hours of the cells exposure. Also, complex showed dose/response depended prooxidant activity and induction of single strand and double strand breaks of DNA. If future experiments show selectively effects of quercetin/lanthanum complex to cancer cells and it's stability in physiological conditions, it can be used in treating patients.

citotoxicity; neutral red assay; comet assay; quercetin/lanthanum complex

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