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Zinc and metallothioneins on cellular immune effectiveness during liver regeneration in young and old mice (CROSBI ID 78285)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Mocchegiani, Eugenio ; Verbanac, Donatella ; Santarelli, Lory ; Tibaldi, Alberto ; Muzzioli, Mario ; Radošević-Stašić, Biserka ; Milin, Čedomila Zinc and metallothioneins on cellular immune effectiveness during liver regeneration in young and old mice // Life sciences, 61 (1997), 12; 1125-1145-x

Podaci o odgovornosti

Mocchegiani, Eugenio ; Verbanac, Donatella ; Santarelli, Lory ; Tibaldi, Alberto ; Muzzioli, Mario ; Radošević-Stašić, Biserka ; Milin, Čedomila

engleski

Zinc and metallothioneins on cellular immune effectiveness during liver regeneration in young and old mice

Partial hepatectomy in young mice (pHx) inuces thymic atrophy, disregulation of thymocytes subsets and a strong accumulation of zinc in thimic tissue after one to two days of liver regeneration. Zinc is relevant for good immune functioning. Restoration of zinc into both the thymus and thymocytes subsets in the late period of liver regeneration is observed in young pHx mice. These findigs have suggested a link between the thymus and the liver influencing T-cell functions and involving zinc. This kind of link could be relevant in aging because thymic involution, negative crude zinc balance, and crippled immune functions are constant events. The preminence of a liver extra thymic T-cell pathway after pHx or during ageing has been suggested. Thus the study of pHx in young and old mice may offer a good model to better understand the role played both by thymic involution and by liver extrathymic T-cell pathway and the role of zinc in these physiological processes during aging. Young pHx mice after one to two days of liver regeneration show: reduced thymic endocryne activity, increment of double negative (DN) thymocytes subsets, imeapment of peripheral immune efficiency (PHA, NK activity and IL-2) and negative crude zinc balance, which are all restored in the late period of liver regeneration. By contrast, the thymic and peripheral immune defects and the negative crude zinc balance, allready present in old sham mice, are not modified during liver regeneration in old pHx mice. circulating leucocytes and lymphocytes are not significantly modified both in young and old pHx mice as compared to respective sham controls. Zinc may also be crucial for extrathymic T-cell pathway, beeing preminent in aging, rather than in young age, due to its metallothioneins (MT) binding capacity. MT are significantly increased in young pHx and in ageing inducing a low zinc-free quota fot thymic and peripheral immune efficiency in young pHx mice, and for extrathymic T-cell pathway, in old age. Thus low zinc bioavailbility, due to MT may play a pivotal role, not only for thymocytes but also for liver extrathymic T-cell pathway.

zinc; metallothioneins; thymulin; immune system; partial hepatectomy; liver growth

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Podaci o izdanju

61 (12)

1997.

1125-1145-x

objavljeno

0024-3205

Povezanost rada

Temeljne medicinske znanosti, Farmacija

Indeksiranost