Pathogenesis of murine cytomegalovirus infection in neonatal mice (CROSBI ID 464063)
Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Trgovcich, Joanne ; Pernjak-Pugel, Ester ; Tomac, Jelena ; Koszinowski, Ulrich H. ; Jonjić, Stipan
engleski
Pathogenesis of murine cytomegalovirus infection in neonatal mice
These findings underscore the utility of the mouse model in investigation of cytomegalovirus pathogenesis in infants. Although congenital transmission does not occur in mice, postnatal infection of neonatal mice reproduces many of the important findings in humans. Furthermore, these studies have highlighted numerous issues, which have yet to be addressed. For example, what is the nature and what are the long-term consequences of virus replication in the bone marrow, CNS and other tissues ; what is the nature of the immune response and role of immune responses in contributing both to virus clearance and pathogenetical changes ; and does virus infection induce chronic or self-limiting inflammatory responses? Furthermore, the finding that the virulence of WT virus is linked to induction of potentially toxic levels of TNF-a represents a previously unrecognized aspect of MCMV pathogenesis. The role of this and other cytokines which may be upregulated during infection are yet to be elucidated. Finally, this model may be particularly important in investigating the basic biology of CMV, including elucidating the roles of viral virulence determinants, such as the fcr gene product, in this virus infection.
perinatal infection; cytomegalovirus; cytokines; immunosurveillance; immunopathology
Monographs in Virology ; Vol. 21 ; ISSN 0077-0965
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Podaci o prilogu
42-53.
1998.
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objavljeno
3-8055-6602-5
Podaci o matičnoj publikaciji
CMV-Related Immunopathology : 1st International Consensus Round Table Meeting
Scholz, M. ; Rabenau, H.F. ; Doerr, H.W. ; Cinatl, J.Jr.
Basel: Karger Publishers
Podaci o skupu
International Consensus Round Table Meeting 81 ; 1997)
poster
01.01.1998-01.01.1998
Frankfurt na Majni, Njemačka