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Pathogenesis of murine cytomegalovirus infection in neonatal mice (CROSBI ID 464063)

Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija

Trgovcich, Joanne ; Pernjak-Pugel, Ester ; Tomac, Jelena ; Koszinowski, Ulrich H. ; Jonjić, Stipan Pathogenesis of murine cytomegalovirus infection in neonatal mice // CMV-Related Immunopathology : 1st International Consensus Round Table Meeting / Scholz, M. ; Rabenau, H.F. ; Doerr, H.W. et al. (ur.). Basel: Karger Publishers, 1998. str. 42-53

Podaci o odgovornosti

Trgovcich, Joanne ; Pernjak-Pugel, Ester ; Tomac, Jelena ; Koszinowski, Ulrich H. ; Jonjić, Stipan

engleski

Pathogenesis of murine cytomegalovirus infection in neonatal mice

These findings underscore the utility of the mouse model in investigation of cytomegalovirus pathogenesis in infants. Although congenital transmission does not occur in mice, postnatal infection of neonatal mice reproduces many of the important findings in humans. Furthermore, these studies have highlighted numerous issues, which have yet to be addressed. For example, what is the nature and what are the long-term consequences of virus replication in the bone marrow, CNS and other tissues ; what is the nature of the immune response and role of immune responses in contributing both to virus clearance and pathogenetical changes ; and does virus infection induce chronic or self-limiting inflammatory responses? Furthermore, the finding that the virulence of WT virus is linked to induction of potentially toxic levels of TNF-a represents a previously unrecognized aspect of MCMV pathogenesis. The role of this and other cytokines which may be upregulated during infection are yet to be elucidated. Finally, this model may be particularly important in investigating the basic biology of CMV, including elucidating the roles of viral virulence determinants, such as the fcr gene product, in this virus infection.

perinatal infection; cytomegalovirus; cytokines; immunosurveillance; immunopathology

Monographs in Virology ; Vol. 21 ; ISSN 0077-0965

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Podaci o prilogu

42-53.

1998.

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objavljeno

3-8055-6602-5

Podaci o matičnoj publikaciji

CMV-Related Immunopathology : 1st International Consensus Round Table Meeting

Scholz, M. ; Rabenau, H.F. ; Doerr, H.W. ; Cinatl, J.Jr.

Basel: Karger Publishers

Podaci o skupu

International Consensus Round Table Meeting 81 ; 1997)

poster

01.01.1998-01.01.1998

Frankfurt na Majni, Njemačka

Povezanost rada

Temeljne medicinske znanosti