Blood selenium, glutathione peroxidase activity and antioxidant supplementation of subjects exposed to arsenic via drinking water (CROSBI ID 155593)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Ćavar, Suzana ; Bošnjak, Zinka ; Klapec, Tomislav ; Barišić, Karmela ; Čepelak, Ivana ; Jurasović, Jasna ; Milić, Marija
engleski
Blood selenium, glutathione peroxidase activity and antioxidant supplementation of subjects exposed to arsenic via drinking water
This work investigated serum selenium (Se) and glutathione peroxidase (GPx) levels in 25 Croatian subjects exposed to high levels of As from drinking water (median As level in urine: 620.74 mug/g creatinine) and 25 controls (32.98 mug/g creatinine). The exposed group had lower (p<0.001) median serum Se and GPx levels (Se: 82.34 vs 59.02 µ ; g/l ; GPx: 45.99 vs 38.38 U/g hemoglobin). A subsample of 20 exposed subjects took part in a two-month antioxidant supplementation trial which increased median GPx activity (30.71 to 40.98 U/g hemoglobin ; p=0.041) and reduced total urinary As (median 680.15 to 501.96 µ ; g/g creatinine ; p=0.051). The effect of selected catalase (-262C>T) and GPx1 (-593C>T) gene polymorphisms was also examined. The low Se status and GPx activity may heighten risk of adverse health effects, especially in genetically predisposed individuals. The outcome of antioxidant treatment indicates modulation of As metabolism and oxidative stress, relevance of which needs further research.
arsenic ; selenium ; glutathione peroxidase ; antioxidants ; catalase ; genetic polymorphisms
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Podaci o izdanju
29 (2)
2010.
138-143
objavljeno
1382-6689
10.1016/j.etap.2009.12.008
Povezanost rada
Kemija, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita