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Conversion of latent to recurrent MCMV infection is primarily controlled by CD8+ T lymphocytes and NK cells (CROSBI ID 464064)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Jonjić, Stipan ; Polić, Bojan ; Zorica, Irena ; Krmpotić, Astrid ; Pavić, Ivica ; Lučin, Pero ; Koszinowski, Ulrich Conversion of latent to recurrent MCMV infection is primarily controlled by CD8+ T lymphocytes and NK cells // 6th International Cytomegalovirus Workshop : Program and Abstracts / Pass, Robert F. (ur.). Orange Beach (AL): UAB School of Medicine, 1997. str. A19-A19-x

Podaci o odgovornosti

Jonjić, Stipan ; Polić, Bojan ; Zorica, Irena ; Krmpotić, Astrid ; Pavić, Ivica ; Lučin, Pero ; Koszinowski, Ulrich

engleski

Conversion of latent to recurrent MCMV infection is primarily controlled by CD8+ T lymphocytes and NK cells

Using B cell-deficient mice we demonstrated previously that antibodies are not essential for the resolution of primary cytomegalovirus infection. here we provide evidence that cell-mediated immune control mechanisms are able to maintain latent MCMV infection in the absence of detectable infectious virus. Depletion of both T cell subsets and NK cells led to recurrent CMV infection in the majority of latently infected B cell-deficient mice within seven days. Recurrent infection did not occur if only one of the subsets was depleted, indicating the functional redundancy of the immune control mechanisms. However, the individual capacity of these cell subsets in controlling of recurrent virus was not equal. In the absence of CD4+ T lymphocytes and NK cells, CD8+ T cells were able maintain nonproductive infection. The absence of CD8+ T cells could be compensated by the synergistic action of CD4+ T lymphocytes and NK cells. Either, CD4+ T cells or NK cells alone, however, were not sufficient to prevent recurrence of productive CMV. Furhermore, IFNg, produced by T cells and NK cells, was essential in CMV control, implicating, at least in part, noncytolytic control mechanisms. Altogether, we postulate that reactivation of latent CMV is a frequent event but the immune control limits viral replication at a stage prior to the production of infectious virus.

latent CMV infection; CD8+ T lymphocytes

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Podaci o prilogu

A19-A19-x.

1997.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

6th International Cytomegalovirus Workshop : Program and Abstracts

Pass, Robert F.

Orange Beach (AL): UAB School of Medicine

Podaci o skupu

6th International Cytomegalovirus Workshop

ostalo

05.03.1997-09.03.1997

Orange Beach (AL), Sjedinjene Američke Države

Povezanost rada

Veterinarska medicina