Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Hepatic metallothioneins and tissue metals in chronic relapsing form of experimental autoimmune encephalomyelitis in rats (CROSBI ID 555169)

Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija

Grebić, Damir ; Jakovac, Hrvoje ; Tota, Marin ; Barac-Latas, Vesna ; Milin, Čedomila ; Mrakovčić-Šutić, Ines ; Radošević-Stašić, Biserka Hepatic metallothioneins and tissue metals in chronic relapsing form of experimental autoimmune encephalomyelitis in rats // 2nd European Congress of Immunology / Reinhold E. Schmidt (ur.). Bolonja: Medimond Monduzzi Editore, 2009. str. 291-297

Podaci o odgovornosti

Grebić, Damir ; Jakovac, Hrvoje ; Tota, Marin ; Barac-Latas, Vesna ; Milin, Čedomila ; Mrakovčić-Šutić, Ines ; Radošević-Stašić, Biserka

engleski

Hepatic metallothioneins and tissue metals in chronic relapsing form of experimental autoimmune encephalomyelitis in rats

Metallothioneins (MTs) are low molecular weight, cysteine-rich proteins that can act as antioxidants and as the immunosuppressive agents in instances of antigen-dependent adaptive immunity. Their induction dramatically increases in response to tissue injury, infection, inflammation and neoplastic disease, showing that they belong to a stress or acute phase proteins. To elucidate the participation of the liver in the pathogenesis of chronic relapsing form of experimental autoimmune encephalomyelitis (CR-EAE), induced in the genetically susceptible DA rats, in this study the hepatic expression of MT I+II and tissue concentrations of Zn2+ and Cu2+ were evaluated during the different phases of disease (in attacks on the 12th and 22nd and remissions on the 18th and 28th post-immunization day). The data revealed that hepatic expression of MTs was markedly enhanced during the time of attacks, as well as that during the first attack of EAE significantly arose the hepatic concentrations Zn2+ and Cu2+ (p<0.0003 in comparison with CFA-treated rats), pointing to the direct participation of the liver in CR-EAE.

liver; metallothioneins; zinc; copper; chronic relapsing encephalomyelitis; DA rats

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

291-297.

2009.

nije evidentirano

objavljeno

978-88-7587-522-0

Podaci o matičnoj publikaciji

2nd European Congress of Immunology

Reinhold E. Schmidt

Bolonja: Medimond Monduzzi Editore

Podaci o skupu

2nd European Congress of Immunology

poster

13.09.2009-16.09.2009

Berlin, Njemačka

Povezanost rada

Temeljne medicinske znanosti