Synthesis and biological evaluation of O-methyl and O-ethyl NSAID hydroxamic acids (CROSBI ID 155721)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Rajić, Zrinka ; Perković, Ivana ; Butula, Ivan ; Zorc, Branka ; Hadjipavlou-Litina, Dimitra ; Pontiki, Eleni ; Pepeljnjak, Stjepan ; Kosalec, Ivan
engleski
Synthesis and biological evaluation of O-methyl and O-ethyl NSAID hydroxamic acids
This paper reports the synthesis of O-methyl and O-ethyl NSAID hydroxamic acids, their antimicrobial activities, and their ability to inhibit urease and soybean lipoxygenase activities. Ibuprofen and fenoprofen hydroxamic acids with free hydroxy groups present the highest antimicrobial activity, while indomethacin and diclofenac analogs show significantly lower antimicrobial activity. Diclofenac hydroxamic acid 4e exerts the highest antiurease activity. Indomethacin O-ethyl hydroxamic acid 3h and ibuprofen O-benzyl hydroxamic acid 4b exert significant inhibitory activities on soybean lipoxygenase. Fenoprofen and indomethacin O-ethyl hydroxamic acids 3b and 3h and diclofenac and indomethacin O-benzyl analogs 4g and 4i highly inhibit lipid peroxidation. The highest antioxidant activity was shown by fenoprofen derivative 3b.
NSAID hydroxamic acids; antimicrobial activity; urease; antioxidant activity; soybean lipoxygenase; inhibition
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Podaci o izdanju
24 (5)
2009.
1179-1187
objavljeno
1475-6366
10.1080/14756360902779128