engleski

Comparision of Digito-palmar Dermatoglyphic Traits in Children with Cerebral Palsy and Their Close Family Members

The prenatal risk factors account for approximately 75% of cerebral palsy cases. The MRI brain scans showed that white-matter damage of immaturity was the most common finding, followed by basal ganglia lesions, cortical/subcortical lesions, malformations, focal infarcts, and miscellaneous lesions while only 11.7% normal MRI findings were present. Since the brain and the dermal ridges develop from the ectoderm at the same time (simultaneously), the environmental as well as genetic factors influencing development of the brain could also have an influence on the dermatoglyphics. Therefore, the aim of the present study was to compare qualitative dermatoglyphic traits in CP children with their first degree relatives and with healthy control group in order to explore the possible genetic predisposition of the disease. Environmental influence would be indicated if dermatogliphic pattern found in CP children would be equally distant from those found in their parents as it is from control group. The study included 60 children (30 boys and 30 girls) with cerebral palsy (CP), their parents (60 fathers and 60 mothers), and 400 phenotypically healthy inhabitants (200 males and 200 females) from the Zagreb area as a control group. The qualitative analyses of the digito-palmar dermatoglyphics in this study comprise frequency of the following patterns on the fingers: whorl, ulnar loop, radial loop, and arch and the pattern frequency in individual parts of the palm: Thenar/I interdigital area, II, III, and IV interdigital area and Hypothenar. The statistical differences have been analyzed by Chi-square test. On fingers, a higher frequency of whorls in boys with CP as well as in their fathers could be observed. Compared to other groups, fathers of the girls with CP show lower frequency of whorls ; instead, they as well as their palsy daughters have higher frequency of radial loops. On the palms a lower frequencies of patterns in the IV interdigital area was observed in both boys and girls with cerebral palsy as well as in their mothers. From this results we clearly can conclude that some genetically influenced diseases affecting the brain could also have expression on dermatoglyphics, which is especially affecting the frequencies of whorls on fingers.

dermatoglyphics; qualitative traits; cerebral palsy; family data

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