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Pregled bibliografske jedinice broj: 431815

Zbornik radova

Autori: Boban, Marina; Šarac, Helena; Mladinov, Mihovil; Süßmair, Christine; Ackl, Nibal; Bader, Benedikt; Danek, Adrian; Hof, Patrick; Šimić, Goran
Naslov: CSF total tau and phosphorylated tau proteins in the differential diagnosis of dementia
Izvornik: Abstracts of the 13th Congress of the European Federation of Neurological Societies ; u: European Journal of Neurology 16 (2009) (S3) / Lenzi, G.L. ; Federico, A. (ur.). - Beč : EFSN , 2009. 343-343.
ISSN: 1351-5101
Skup: Congress of the European Federation of Neurological Societies (13 ; 2009)
Mjesto i datum: Firenca, Italija, 12.-15.09.2009.
Ključne riječi: aging; Alzheimer's disease; cerebrospinal fluid; dementia; early diagnosis; ELISA; neurofibrillary degeneration; tau protein
Sažetak:
Alzheimer’ s disease (AD) and frontotemporal dementia (FTD) represent an important differential diagnostic problem in clinical practice. The identification for new biomarkers that would help establishing the diagnosis and primary cause of the dementia is therefore of great relevance. The aim of this study was to investigate the diagnostic accuracy of three potential CSF biomarkers, total tau protein (t-tau), tau protein phosphorylated at threonine 181 (p-tau181) and tau protein phosphorylated at serine 199 (p-tau199), in the differential diagnosis of AD and FTD patients in relatively young age groups. The concentrations of these three CSF biomarkers were measured in 25 FTD patients, 27 AD patients and 25 control subjects. The CSF concentrations of all three markers were significantly higher in AD than in FTD patients (p<0.001) or control subjects (p<0.001). No difference was observed in FTD patient group compared to controls, except for p-tau181 (p=0.028).When sensitivity was set at 85% or higher, specificity in differentiation between FTD and AD patients reached 40% for t-tau, 37.5% for p-tau181 and 56% for p-tau199. Improvement of the diagnostic accuracy upon logistic regression analysis with t-tau and p-tau199 as independent variables showed that 22 out of 25 FTD patients could be correctly classified. In conclusion, none of the markers per se fulfilled the criteria for the “ ideal” marker (sensitivity and specificity higher than 85%). However, combination of t-tau and p-tau199 detected correctly 88% of FTD patients, thus largely satisfying practical requirements.
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bazama podataka:
MEDLINE
Current Contents Citation Index
Web of Science: Science Citation Index Expanded
Web of Science: Science Citation
Scopus
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 108-1081870-1942
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Psihologija
Upisao u CROSBI: gsimic@mef.hr (gsimic@mef.hr), 27. Lis. 2009. u 12:12 sati



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