Crystallography in bioanalysis (CROSBI ID 556238)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Matković-Čalogović, Dubravka ; Milić, Dalibor ; Đilović, Ivica ; Prugovečki, Biserka
engleski
Crystallography in bioanalysis
For characterization of a compound, either a small molecule or a macromolecule, information about structure and properties is needed. If the compound can be crystallized then X-ray diffraction analysis gives a lot of information about the molecular and crystal structure. Crstallization of proteins is difficult and can be a bottleneck for such analysis. Our newest results in protein crystallography will be briefly discussed: (1) enzymatic activity of tyrosine phenol-lyase (TPL) could be deduced by detailed structural analysis of native and mutated TPL forms in complexes with substrate analogues ; (2) 3-hydroxyanthranilate 3, 4-dioxygenase, enzyme that catalyzes the conversion of 3-hydroxyanthranilate to quinolinic acid, has been extracted and purified from bovine kidney, crystallized and its structure determined at 2.5 Å ; resolution ; (3) coordination of iron in bovine insulin changed upon addition of bromide or iodide ions into crystallization solutions.
crystallography; bioanalysis
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
2009.
objavljeno
Podaci o matičnoj publikaciji
Book of Abstracts, CEEPUS International Symposium and Summer School on Bioanalysis
T. Pajpanova, T. Dzimbova
Blagoevgrad:
Podaci o skupu
CEEPUS International Symposium and Summer School on Bioanalysis
ostalo
06.09.2009-12.09.2009
Blagoevgrad, Bugarska