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Immunogenicity and Safety of Queensland V4 and Ulster 2C strains of Newcastle Disease Virus Given to Maternally Immune, Newly Hatched Chickens by Nebulisation

Commercial chickens with a high level of maternal antibodies for Newcastle disease were vaccinated when newly hatched with Queensland V4 or Ulster 2C NDV strains by nebulisation. The exposure time to a fine aerosol of vaccine produced with an ultrasonic nebuliser was 60 seconds. The chickens were challenged oculonasally with virulent NDV strain Texas GB in weekly intervals up to the 49th day of life, and were well protected. There was good agreement between the dose of virus and level of specific antibodies achieved. Nebulisation of these lentogenic strains of NDV was safe and highly immunogenic. Vaccinal reactions were not observed. Queensland V4 produced higher titres than Ulster 2C and provided better protection to challenge.

Newcastle disease virus ; Queensland V4 ; Ulster 2C ; live virus ; vaccination ; aerosol

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