Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives (CROSBI ID 156733)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Radić Stojković, Marijana ; Marjanović, Marko ; Pawlica, Dariusz ; Dudek, Lukasz ; Eilmes, Julita ; Kralj, Marijeta ; Piantanida, Ivo
engleski
Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives
Studied dicationic dibenzotetraaza[14]annulene derivatives intercalate into synthetic double stranded DNA and RNA, while their positively charged side-chains additionally interact within the minor groove of polynucleotides, contributing to the overall affinity of compounds and controlling pronounced A-T(U) over G-C sequence preference as well as stronger thermal stabilization of ds-DNA than ds-RNA. Furthermore, all compounds showed moderate to high antiproliferative activity against five human tumour cell lines, whereby clear correlation between structure of the side-chain and cytotoxic activity was observed.
dibenzotetraaza[14]annulene ; DNA and RNA polynucleotides ; spectrophotometric titrations ; antiproliferative activity ; tumour cell lines
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Podaci o izdanju
Povezanost rada
Kemija, Biologija, Temeljne medicinske znanosti