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DNA-protective effects of EGCG and propolis in alloxan–induced diabetic mice

Free radicals have been implicated in playing a role in over 100 diseases, including cancer, atherosclerosis, rheumatoid arthritis, inflammatory bowel disease, diabetes, asthma, cardiovascular disease, liver disease, and other inflammatory processes. There is growing recognition that many polyphenolic compounds presents in most plants and bee products such as propolis, may have beneficial effect on human health. Tea catechins are polyphenolic flavonoids which have been found to possess widespread biological functions including obesity and diabetes. Tea catechins, especially (–)-epigallocatechin gallate (EGCG), appear to have antiobesity and antidiabetic effects. The present study was designed to elucidate the antidiabetic effect of (–)-epicatechin and propolis in alloxan-induced diabetes in mice. Intraperitoneal administration of (–)-epicatechin or propolis at doses of 50 mg/kg to diabetic mice for a period of 7 days resulted in a significant changes in body weight, haematological and some biochemical parameter of blood. (–)-Epicatechin at a dose of 50 mg/kg was found to be more effective than propolis. Additionally mouse blood lymphocytes were utilized to check for possible protective effects of EGCG or propolis against alloxan-induced oxidative DNA-damage. EGCG or propolis significantly reduces oxidative cell damage in diabetic mice. The results from the genotoxicity studies suggest EGCG or propolis is safe for consumption with no observed adverse effect

cancer; propolis; polyphenols; EGCG; alloxan

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