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CD138-positive plasmacytoid urothelial carcinoma of urinary bladder with focal micropapillary features

Both plasmacytoid and micropapillary type of urothelial carcinoma of urinary bladder are uncommon, distinct clinical and pathological findings. To date, several reports in English literature have been published on the plasmacytoid and micropapillary variants of urothelial carcinoma, separately. CD138 is usually used as a marker for tumors of plasma cell origin. However, few authors have described positive immunoreactivity of plasmacytoid cells in urothelial carcinoma of urinary bladder. Mixed histologic differentiation of urothelial carcinoma is thought to be a phenotype of locally aggressive and advanced urothelial carcinoma. Therefore, precise pathohistological diagnosis should be made and the awareness of all the entities is crucial. We report a case of CD138-positive plasmacytoid urothelial carcinoma of urinary bladder with focal micropapillary features. To our knowledge this is the first case of these two rare subtypes of urothelial carcinoma combined in a single cystectomy specimen.

CD-138; micropapillary; plasmacytoid; urothelial carcinoma

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