Thermodynamics of nanospheres encapsulated in virus capsids (CROSBI ID 557562)
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Podaci o odgovornosti
Šiber, Antonio ; Zandi, Roya ; Podgornik, Rudolf
engleski
Thermodynamics of nanospheres encapsulated in virus capsids
We investigate the thermodynamics of complexation of functionalized charged nano-spheres with viral proteins. The physics of this problem is governed by electrostatic interaction between the proteins and the nanosphere cores (screened by salt ions), but also by configurational degrees of freedom of the charged protein N-tails. We approach the problem by constructing an appropriate complexation free energy functional. On the basis of both numerical and analytical studies of this functional we construct the phase diagram for the assembly which contains the information on the assembled structures that appear in the thermodynamical equilibrium, depending on the size and surface charge density of the nanosphere cores. We show that both the nano-sphere core charge as well as its radius determine the size of the capsid that forms around the core.
virus; capsid; protein; electrostatics; assembly; gold
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Podaci o prilogu
14-14.
2009.
objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
4th Christmas Biophysics Workshop, Soft Matter meets Biological Physics
predavanje
14.12.2009-15.12.2009
Leibnitz, Austrija