engleski

The novel acyclic purine nucleoside analogues as potential antiviral agents : synthetic, X-ray crystal structure, computational and NMR studies

Open chain sugar analogues of nucleoside have been made the object of intensive chemical and pharmacological investigation due to their potential activity as antiviral agents. A large number of such acyclic nucleoside analogues have been synthesised, but only few of them have been found to possess potent antiviral activity against HIV. This investigation is concerned with the synthesis of the novel 6-(N-pyrrolyl)purine and adenine nucleoside analogues with acyclic side chains attached to the purine ring at N-9 and N-7 (Scheme). The site of alkylation was deduced on the basis of 1H and 13C NMR spectra by using analysis of chemical shifts, coupling constants and connectivities in NOESY and heteronuclear correlation spectra

acyclic purine nucleoside analogues ; antiviral agents ; synthesis ; x-ray crystallography ; 1H and 13C NMR studies

Rad je kao poster prezentiran i na skupu 11th European Symposium on Quantitative Structure-Activity Relationships : Computer-Assisted Lead Finding and Optimization, održanom od 01.-06.09.1996., Lausanne, Švicarska ; uz međunarodnu recenziju objavljen u Knjizi sažetaka ; 1996. ; str. 25-25.