engleski

The novel acyclic purine nucleoside analogues as potential antiviral agents : synthetic, NMR and X-ray crystal structure study

A large number of the open-chain sugar analogues of nucleoside have been made the object of intensive chemical and pharmacological investigation due to their potential activity as antiviral and anti-HIV agents. This investigation is concerned with the synthesis of the novel 6-(N-pyrrolyl)purine and adenine nucleoside analogues with acyclic side chains attached to the purine ring at N-9 and N-7 (Scheme). The site of alkylation was deduced on the basis of 1H and 13C NMR spectra by using analysis of chemical shifts, coupling constants and connectivities in NOESY and heteronuclear correlation spectra

acyclic purine nucleoside analogues; antiviral agents; synthesis; NMR spectroscopy; x-ray crystallography

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