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Crystal Structure Study of N-Methyl-6,7-dihydro- 1,11-dimethyl-5H-dibenz/c,e/azepine

The dihydrobenzazepine derivatives has been proved to posses potent hypolipidemic activities, the treatment with 6, 7-dihydro-5H-dibenz/c, e/azepine resulted in a reduction of cgolesterol, neutral lipid, and triglyceride content in mouse and rat liver. In the search for compounds related to that class of pharmacologically active compounds we have prepared and structural elucidated the title compound. X-ray quality crystals were grown by slow evaporation of a very dilute solution of ethylacetate ethanol mixture (1:5). Crystal data: C_17H_19N, M_r = 237.33, monoclinic group, space group P2_1/n ; a = 9.163(2) Ĺ, b = 9.317(2) Ĺ, c = 16.593(4) Ĺ, beta = 106.03(3)^o, V = 1361.5(5) Ĺ^3, D_x = 1.158 g cm^-3, Z = 4, F(000) = 205, MoK_alpha radiation, R = 0.0465, R_w= 0.1114, 205 parameters, 972 reflections with I more or equal 2 sigma(I) used in the refinement. The molecule of (+/-) N-Methyl-6, 7-dihydro-1, 11- dimethyl-5H- dibenz/c, e/azepine showed the expected cisoid arrangement around the C12-C14 bond with an interplanar dihedral angle C1-C14-C12-C11 of 60.6(4)^o. The torsion angles C5-N-C7-C13 and C7- N-C5- C15 were found to be 44.1(3)^o and 43.8(3)^o, respectively, indicating the C-N-C-C bonds adopt the expected gauche arrangement. Generally, the 7-membered azepine ring adopt a boat conformation

crystal structure ; dihydrobenzazepine derivatives

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