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Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9) : Study of 145 Patients (CROSBI ID 159061)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Polašek, Ozren ; Gunjača, Grgo ; Kolčić, Ivana ; Zgaga, Lina ; Džijan, Snježana ; Smolić, Robert ; Smolić, Martina ; Milas-Ahić, Jasminka ; Šerić, Vatroslav ; Galić, Josip et al. Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9) : Study of 145 Patients // Croatian medical journal, 51 (2010), 1; 48-53. doi: 10.3325/cmj.2010.51.48

Podaci o odgovornosti

Polašek, Ozren ; Gunjača, Grgo ; Kolčić, Ivana ; Zgaga, Lina ; Džijan, Snježana ; Smolić, Robert ; Smolić, Martina ; Milas-Ahić, Jasminka ; Šerić, Vatroslav ; Galić, Josip ; Tucak-Zorić, Sandra ; Tucak, Antun ; Rudan, Igor ; Lauc, Gordan

engleski

Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9) : Study of 145 Patients

To investigate the association of nephrolithiasis and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9. A total of 145 participants were recruited in the period April-October 2008 from the Department of Mineral Research at the Medical School Osijek, Osijek, Croatia ; 58 (40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic. Four single nucleotide polymorphisms (SNP) from the SLC2A9 gene were genotyped in both groups (rs733175, rs6449213, rs1014290, and rs737267). There was a weak but significant association of all 4 SNPs and nephrolithiasis (P=0.029 for rs733175 ; P=0.006 for rs6449213 ; P=0.020 for rs1014290, and P=0.011 for rs737267). Logistic regression in an age- and sex-adjusted model suggested that genotype C/T for rs6449213 had odds ratio for nephrolithiasis of 2.89 (95% confidence interval, 1.13-7.40). This SNP explained a total of 4.4% of nephrolithiasis variance. Development of nephrolithiasis may be associated with SLC2A9 gene. Further studies are needed to clarify the role of SLC2A9 gene as a link between uric acid and nephrolithiasis.

nephrolithiasis; uric acid; SLC2A9

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Podaci o izdanju

51 (1)

2010.

48-53

objavljeno

0353-9504

10.3325/cmj.2010.51.48

Povezanost rada

Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Biologija

Poveznice
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