Increased expression of matrix metalloproteinase-1 in uterosacral ligament tissue from women with pelvic organ prolapse (CROSBI ID 159235)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Strinić, Tomislav ; Vulić, Marko ; Tomić, Snježana ; Ćapkun, Vesna ; Stipić, Ivica ; Alujević, Ivana
engleski
Increased expression of matrix metalloproteinase-1 in uterosacral ligament tissue from women with pelvic organ prolapse
Mechanical stability of the urogenital tract depends on intact collagen fibers. Because of difficulties in quantitating collagen, some authors have investigated collagen breakdown by measuring matrix metalloproteinases expression. We biopsied 68 post-menopausal women during operation to evaluate matrix metalloproteinase-1 (MMP-1) expression in uterosacral ligament biopsies from women with pelvic organ prolapse (POP) (n = 34) and controls with normal pelvic support (n = 34). The controls were matched to the POP group by age, body mass index, parity and duration of postmenopausal state. Immunohistochemistry for MMP-1 was performed on formalin fixed and paraffin embedded sections. Women with POP had a significantly higher MMP-1 expression (p = 0.047) which confirms an association, although not a causal relation, between POP and increased MMP-1 expression.
MMP-1 ; immunohistochemistry ; POP
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
89 (6)
2010.
832-834
objavljeno
0001-6349
10.3109/00016341003592545
Povezanost rada
Kliničke medicinske znanosti