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izvor podataka: crosbi

Immunolocalization and mRNA expression of bone morphogenetic protein-6 in human clear cell renal carcinoma. (CROSBI ID 159851)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Bašić-Jukić, Nikolina ; Radić-Antolić, Margareta ; Hudolin, Tvrtko ; Ćorić, Marijana ; Zadro, Renata ; Pasini, Josip ; Kaštelan, Željko ; Kes, Petar Immunolocalization and mRNA expression of bone morphogenetic protein-6 in human clear cell renal carcinoma. // Kidney & blood pressure research, 32 (2009), 4; 445-450. doi: 10.1159/000266479

Podaci o odgovornosti

Bašić-Jukić, Nikolina ; Radić-Antolić, Margareta ; Hudolin, Tvrtko ; Ćorić, Marijana ; Zadro, Renata ; Pasini, Josip ; Kaštelan, Željko ; Kes, Petar

engleski

Immunolocalization and mRNA expression of bone morphogenetic protein-6 in human clear cell renal carcinoma.

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta superfamily of proteins. Dysregulation of BMP signaling has been suggested in the carcinogenesis of different organs. We determined BMP-6 mRNA and protein expression in localized human clear cell renal carcinoma (CCRC), obtained from 20 patients who underwent nephrectomy, by the real-time polymerase chain reaction and immunohistochemistry. 15/20 patients exhibited higher BMP-6 mRNA expression in malignant than in healthy renal tissue relative to the PBGD expression (p < 0.05). Immunostaining intensity for BMP-6 in healthy renal tissue ranged from 0 to 2 (average 0.9), as well as in renal clear cell carcinoma (average 1.1). Seven of 20 (35%) healthy tissue samples failed to stain with BMP-6 antibody, compared to 2/20 (10%) tumor samples (p < 0.05). BMP-6 immunostaining was positive in 18/20 CCRC samples. Staining was localized in the cytoplasm and/or membrane of malignant cells. Malignant tissue had significantly higher BMP-6 mRNA expression than healthy tissue. There was no significant correlation between BMP-6 mRNA and protein expression with disease presentation, disease progression and patients' characteristics. Long-term follow-up of our patients is needed to determine the possible role of increased expression of BMP-6 in CCRC.

BMP-6; clear cell renal carcinoma; expression

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Podaci o izdanju

32 (4)

2009.

445-450

objavljeno

1420-4096

10.1159/000266479

Povezanost rada

Temeljne medicinske znanosti

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