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Comparison between Coefficients of Inbreeding Computed from Deficit of Heterozygotes for Codominant Autosomal Genetic Polymorphisms and from Isonymy data: A Study of Hvar Island Isolates, Croatia (CROSBI ID 25149)

Prilog u knjizi | izvorni znanstveni rad

Rudan, Igor ; Rudan, Pavao Comparison between Coefficients of Inbreeding Computed from Deficit of Heterozygotes for Codominant Autosomal Genetic Polymorphisms and from Isonymy data: A Study of Hvar Island Isolates, Croatia // Human Population Genetics in Europe / Sussanne, Charles ; Bodzsar, Eva B. (ur.). Budimpešta: Eötvös József College Press, 2000. str. 117-128-x

Podaci o odgovornosti

Rudan, Igor ; Rudan, Pavao

engleski

Comparison between Coefficients of Inbreeding Computed from Deficit of Heterozygotes for Codominant Autosomal Genetic Polymorphisms and from Isonymy data: A Study of Hvar Island Isolates, Croatia

The aim of this study was to compare the values of the coefficient of inbreeding determinated from isonymy data and the one determinated from deviation from Hardy-Weinberg expectations in phenotype (and genotype) frequencies of heterozygotes for codominant, biallelic autosomal genetic polymorphisms, in this case erythrocyte antigens of MN-system, S-system and Kell-system. The study was performed in a sample of Hvar island population, presumed to be highly inbred. The study involved a total of 593 marital pairs (1186 individuals) and a blood sample was collected from 968 of them (81, 6%). The value of inbreeding coefficient determinated from MN-system was 32, 2%, S-system 2, 6%, Kell system 13, 1% and from isonymy 2, 3%. The reasons for the underestimation of the inbreeding coefficient from isonymy data in subdivided populations are discussed, with special consideration to factors affecting effective size, Wahlund’d principle, visible or invisible barriers to panmyxia, and “surname drift” over long time period.

inbreeding coefficients, autosomal genetic polymorphisms, isonymy, population genetics, anthropology

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Podaci o prilogu

117-128-x.

objavljeno

Podaci o knjizi

Human Population Genetics in Europe

Sussanne, Charles ; Bodzsar, Eva B.

Budimpešta: Eötvös József College Press

2000.

963-9316-12-1

Povezanost rada

Etnologija i antropologija