engleski

Prolactin response in patients with schizophrenia treated with haloperidol, clozapine, risperidone and olanzapine

Background: The aim of our study was to investigate the prolactin (PRL) response after speci3c dopaminergic probe with sulpiride as well as seroto-nergic probe with clomipramine in patients with schizophrenia treated with clozapine, olanzapine, risperidone, and haloperidol. Materials and methods: Male patients (N = 44) diagnosed with schizophrenia according to DSM IV criteria were in cluded in the study. Neuroendoc-rine assessment included the determination of PRL levels after speci3c dopaminergic probe with sulpiride and serotonergic probe with clomipramine. Results: Mean basal PRL levels differed significantly between groups (P < 0.001). Post-hoc Sche>é test revealed significant difference between haloperidol group vs. all three other subgroups (clozapine, olanzapine, and risperidone). Furthermore, mean δPRL level after sulpiride (P < 0.001) as well as after clomipramine (P < 0.001) induction also differed significantly between patient subgroups. Conclusions: There is a difference in PRL response after dopaminergic and serotonergic probe in patients with schizophrenia treated with clozapine, olanzapine, risperidone and haloperidol. We hypothesize that this different response in neuroendocrine model might probably be due to neurotransmit-ter systems being occupied by different antipsychotic drugs.

Antipsychotics drugs; dopamine; Prolactin; Schizophrenia; Serotonin

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