engleski

Effect of three-day ACTH administration on concentrations of cholesterol, cortisol, progesterone, testosterone and LH in the boars

The objective of this study was to investigate effects of stress induced by ACTH on cholesterol, cortisol, progesterone, testosterone and LH concentrations in Swedish Landrace boars aged 6 to 7 months during ACTH administration and for 12 days after the cessation of treatment. ACTH treated boars (n14) were given intravenously 10 g/kg of ACTH for 3 days. Control group (n14) received intramuscularly 1 mL of sterile 0.9% saline. The cortisol concentrations were significantly elevated (p<0.0001, all) in all three days of ACTH treatment and day after the last ACTH injection (p0.01) in treated boars. In twelve days after the cessation of treatment, cortisol levels remained on physiological levels. During all three ACTH treatment days and also one day and five days after the last ACTH dosage, cholesterol concentrations were significantly decreased (p<0.05 to p<0.0001, respectively) in comparison with control boars. Progesterone and testosterone concentrations were significantly increased (p<0.001 to p<0.0001, respectively) during all three days of ACTH treatment. After the treatment there was no significant difference in progesterone and testosterone levels between treated and control boars. ACTH administration had no influence on LH levels in treated boars. Significantly reduced cholesterol concentrations in the serum of boars exposed to three-day ACTH induced stress shows its increased biotransformation, which is confirmed by the results of this paper.

Boars; ACTH; Stress; Cortisol; Hormones; Cholesterol

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