MCMV infection in newborn mouse brain (CROSBI ID 560133)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Pernjak Pugel, Ester ; Cekinović, Đurđica ; Bantug, Glenn ; Koontz, Thad ; Tomac, Jelena ; Britt, William ; Jonjić, Stipan
engleski
MCMV infection in newborn mouse brain
Congenital human cytomegalovirus (HCMV) infection frequently results in widespread encephalitis and developmental abnormalities of newborn brain. Animal models of congenital HCMV infection are essential for understanding the pathogenesis of cytomegalovirus (CMV) infection in developing central nervous system (CNS). We have recently described a mouse model of CMV infection in developing brain using peripheral inoculation of newborn mice with mouse CMV (MCMV). The virus replication in peripheral tissues was followed by viral spread to CNS, resulting in focal infection and inflammation of developing brain. As a consequence, normal developmental tissue program was altered, resulting in delayed cerebellar morphogenesis and disturbed cellular positioning in brain of MCMV-infected mice. Clearance of infectious virus from brain of newborn mice involved the activation of both innate and acquired immune response.
brain; MCMV infection
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
S709-S709.
2009.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
European journal of immunology
0014-2980
Podaci o skupu
European Congress of Immunology (2 ; 2009)
poster
13.09.2009-16.09.2009
Berlin, Njemačka
Povezanost rada
Temeljne medicinske znanosti