engleski

Association between Infection Aspects in Women with Squamous Intraepithelial Lesions and Peniscopic Findings in Their Male Sexual Partners

Objectives were to connect colposcopy of women having squamous intraepithelial lesions (SIL) and peniscopic findings in their male sexual partners, to determine the prevalence of human papillomavirus (HPV) DNA in the male partners of women affected by SIL, and to assess the concordance of the viral group in the infected pair. 27 females with different grade of SIL were examined by cytology, colposcopy and histology and 27 their male sexual partners underwent clinical examination, peniscopy and biopsy. HPV testing was performed for all. 50% of the sexual partners of women with low grade squamous intraepithelial lesions (LSIL) were peniscopically negative. 36% of the male partners of women with high grade squamous intraepithelial lesions (HSIL) were peniscopically negative. Clinical lesions were observed in 50% and 9% of the sexual partners of women with LSIL and HSIL, while subclinical lesions were found only in male partners of women with HSIL (45%). Male partner of women with vaginal intra-epitelial (VAIN) was HPV negative. Sexual partners of women with LSIL enrolled in our study were not HPV positive. Male partners of patients with HSIL were HPV positive in 63% cases with 59% being infected with high-risk viruses and 4% with low-risk HPV viruses. The same genotypes were found in 19% of couples, similarity in one genotype and difference in other was found in 29.6% couples, while complete discorcondance was found in 48% of couples. Highest concordance was achived by high-risk types, especially type 16. The majority of penile lesions was associated with the detection of mostly high-risk HPV types, while condylomata acuminata was associated with HPV high-risk types in only 25%. Male sexual partners of women with SIL lesions have penile lesions determined by peniscopical examination that are mostly associated with the presence of high-risk HPV in women with HSIL. High-risk HPV among male partners with clinical and specially subclinical penile manifestations suggests that they constitute a reservoire for future clinical manifestation or virus transmission. Concordance of the viral group in infected pair needs to be more elucidated.

Squamous intraepithelial; colposcopy; peniscopy; HPV

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