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Unique collection of the compounds stored within PLIVA’s Compounds Library (CROSBI ID 560666)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija

Jelić, Dubravko ; Mesar, Vesna ; Nadramija, Damir ; Verbanac, Donatella Unique collection of the compounds stored within PLIVA’s Compounds Library // 1st CCOMLIS (1st Croatian Congress on Molecular Life Science) with international participation - Book of Abstracts / Dumić, Jerka et al. (ur.). Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2002. str. 114-114

Podaci o odgovornosti

Jelić, Dubravko ; Mesar, Vesna ; Nadramija, Damir ; Verbanac, Donatella

engleski

Unique collection of the compounds stored within PLIVA’s Compounds Library

The drug discovery process is long and expensive. With the aim to shorten this process by producing and/or collecting high-quality drug-like compounds, which generate quality valuable data from High Throughput Screening, about two years ago we established new PLIVA's Compound Library. Our HTS collection consists of over 25.000 organic compounds, produced by us or acquired from different companies or even collected from various sources. The Library consists of many different structural classes. These are handcrafted compounds, produced by original synthetic techniques, often unique to PLIVA. These techniques have been developed by us, based on 80 years of experience in medicinal chemistry. The compounds in our collection are diverse ; most of them follow Lipinski Rule of Five, which describes the characteristics of chemical compounds with a stronger prospect of becoming potential drug candidates relative to other molecules. But, rules are not absolute and should not be used to immediately eliminate compounds from consideration. Best exception of these rules is Azithromycin, successful “blockbuster” and powerful PLIVA-s antibiotic. We are trying to achieve high quality and have sufficient amounts necessary to perform screening on selected targets. Our compounds undergo rigorous analysis before becoming recorded as PL compounds (unique PLIVA's code). The structures are typically confirmed by LC-MS and H1NMR. Compounds are stored in vials and microtitar plates, and we are producing our own mother-plates for targeted screening. Our PLIVA Compounds Library and a data produced from HTS are important part of the PLIVA R&D Database, developed and maintained by Research Information Center, where many UserClient applications are built as a support of R&D.

compound library; screening; HTS; lipinski rule of 5

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Podaci o prilogu

114-114.

2002.

objavljeno

Podaci o matičnoj publikaciji

1st CCOMLIS (1st Croatian Congress on Molecular Life Science) with international participation - Book of Abstracts

Dumić, Jerka et al.

Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu

953-6256-13-4

Podaci o skupu

1st CCOMLIS (1st Croatian Congress on Molecular Life Science) with international participation

poster

09.06.2002-13.06.2002

Opatija, Hrvatska

Povezanost rada

Kemija, Temeljne medicinske znanosti, Biologija