engleski

Vitamin D serum level and BMD of premenopausal and postmenopausal women in Croatia

The aim of this study was to evaluate the vitamin D status and BMD of premenopausal and postmenopausal women. We conducted a cross-sectional observational study of 790 women. The age range was 44-78 years. Serum 25(OH) vitamin D was assayed in each patient. Spine and proximal femur BMD were measured by dual X-ray absorptiometry. Women were divided into 3 groups: 1. group consisted of 70 younger women with regular menstrual status, 2. group was consisted of 240 postmenopausal womenwithin 5 years since menopause, 3. group was consisted of 480 postmenopausal women with more than 5 years since menopause. Based on data in the literature, we used four 25(OH) vitamin D cutoffs to define vitamin D deficiency: 30, 50, 75 and more than 75 nmol/L. Vitamin D serum level was found in 8.02%, 24.1%, 30.3% and 36.7% with 30, 50, 75 and more than 75 nmol/L cutoffs, respectively. The mean serum 25(OH) vitamin D level was 60.81±26, 1 nmol/L, 67.25±21.4 nmol/L, and 68.86± 18.1 nmol/L with the first to the third group of women, respectively. 25(OH) vitamin D serum level slightly increases with age in women but not statisticaly significant. Measurement of BMD and DEXA have show osteopenia or osteoporosis are even present in younger women with regular menstrual status. Such women have lower than 30 nmol/L of serum vitamin D level. The number opf women who has osteopenia or osteoporosis increase with age. In these groups serum vitamin D level is in negative correlation with BMD. In the third group the prevalence of osteoporosis is the highest. The mean characteristic of the first group of women is that vitamin D deficiencycorrelates with osteopenia or osteoporosis. This study showed correlation among low serum vitamin D level and osteopenia or osteoporosis in younger women with regular menstrual status.

vitamin D; BMD; osteopenia; osteoporosis

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