BMP-6 and mesenchymal stem cell differentiation (CROSBI ID 161818)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Vukičević, Slobodan ; Grgurević, Lovorka
engleski
BMP-6 and mesenchymal stem cell differentiation
Bone morphogenetic protein-6 (BMP-6) is produced by bone marrow-mesenchymal (BMSC) and hematopoietic stem cells, which can differentiate into bone, cartilage, adipose, muscle, hematopoietic, synovial and other tissues. Bmp6-/- null mice have low hepcidin serum levels and an iron overload, resembling hereditary hemochromatosis, which may cause a reduced number of pancreatic beta-cells, increased serum glucose and diabetes. BMP-6 circulates in the normal human plasma and is produced by BMSC prior to differentiation into osteoblasts. Moreover, it is also released by osteoclasts as a key bone coupling factor recruiting osteoblasts to the resorption site. Due to unique structural, receptor binding and signaling characteristics much smaller amounts of BMP-6 than BMP-7 are needed in vivo to induce regeneration of bone defects in animals.
bone marrow-mesenchymal cells (BMSC); bone morphogenetic protein-6 (BMP-6); Bmp−/− mouse; iron metabolism; glucose regulation; diabetes; bone formation; coupling of bone formation to resorption; macrophage; synovial cells; cartilage repair; osteogenic transcription factors; BMP-6 receptors; BMP-6 structure
Bone Morphogenetic Proteins, Stem Cells and Regenerative Medicine ; A. Hari Reddi (Ed.)
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Podaci o izdanju
20 (5-6)
2009.
441-448
objavljeno
1359-6101
10.1016/j.cytogfr.2009.10.020
Povezanost rada
Temeljne medicinske znanosti