engleski

5-HT2A receptor gene polymorphisms in Croatian subjects with autistic disorder

Disturbances in expression/function of 5-HT2A receptor are implicated in autism. Association of 5-HT2A receptor gene with autism was studied in Croatian population. Distribution frequencies for alleles, genotypes and haplotypes of -1438 A/G and His452Tyr polymorphisms were compared in samples of 103 autistic and 214 control subjects. Significant overrepresentation of G allele and GG genotype of -1438 A/G polymorphism was observed in group of autistic subjects, supporting possible involvement of 5-HT2A receptor in development of autism.

serotonin ; -1438 A/G ; His452Tyr

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