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Production of prostaglandin E by squamous carcinoma of the head and neck and adenocarcinoma of gastrointestinal tissue (CROSBI ID 161968)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Čulo, Filip ; Klapan, Ivica ; Katić, Vladimir ; Kolak, Toni ; Bakula, Branko Production of prostaglandin E by squamous carcinoma of the head and neck and adenocarcinoma of gastrointestinal tissue // Medical oncology and tumor pharmacotherapy, 9 (1992), 1; 35-39. doi: 10.1007/BF02989651

Podaci o odgovornosti

Čulo, Filip ; Klapan, Ivica ; Katić, Vladimir ; Kolak, Toni ; Bakula, Branko

engleski

Production of prostaglandin E by squamous carcinoma of the head and neck and adenocarcinoma of gastrointestinal tissue

The production of prostaglandin E ex vivo was studied in samples of 31 squamous cell carcinomas of the head and neck (SCCtlN) and 12 adenocareinomas of gastrointestinal tract (ACGI). As a control, the PGE production was measured in 22 samples of noninvolved mucosa in patients with SCCHN and 12 samples of gastrointestinal mucosas. The mean PGE production by SCCHN was significantly higher than in normal mucosa. Furthermore, the PGE production by tumors which recurred or spread to regional lymph node within 18 months after surgery was higher than in tumors which did not recur within that interval. Also, production of PGE by noninvolved mucosa was significantly higher in patients in which tumor recurred after surgery than in patients which were tmnor free. On the other hand, the mean production of PGE by ACGI was not different from that of normal mucosa. These data show that determination of PGE production might have prognostic significance in SCCHN.

head and neck cancer ; gastrointestinal cancer ; PGE

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Podaci o izdanju

9 (1)

1992.

35-39

objavljeno

0736-0118

10.1007/BF02989651

Povezanost rada

Kliničke medicinske znanosti, Temeljne medicinske znanosti

Poveznice
Indeksiranost