engleski

Genomics in multiple sclerosis

Multiple sclerosis (MS) is chronic, inflammatory disease of the central nervous system that mainly affects young adults and is characterized with demyelination. It is well known that MS is very heterogeneous disease, so biomarkers that would reliably determine disease course, outcome or treatment response in early stages of the disease (preferentially clinically isolated syndrome) are desperately needed. Genomic analysis of expression profiles represents the profile or imprint of all genes in certain tissue or cell population in certain time point. As human genome is entirely known, it is possible to analyze any given human gene in any given context. This review will discuss results and possible applications of gnome-wide expression studies in brain tissue and blood samples of MS patients.

multiple sclerosis; biomarkers; genomics; microarrays

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