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Diagnostic approach for precancerous and early invasive cancerous lesions of the uterine cervix (CROSBI ID 162586)

Prilog u časopisu | pregledni rad (stručni)

Grubišić, Goran ; Klarić, Petar ; Jokanović, Ljubomir ; Soljačić Vraneš, Hrvojka ; Grbavac, Ivan ; Bolanča, Ivan Diagnostic approach for precancerous and early invasive cancerous lesions of the uterine cervix // Collegium antropologicum, 33 (2009), 4; 1431-1436

Podaci o odgovornosti

Grubišić, Goran ; Klarić, Petar ; Jokanović, Ljubomir ; Soljačić Vraneš, Hrvojka ; Grbavac, Ivan ; Bolanča, Ivan

engleski

Diagnostic approach for precancerous and early invasive cancerous lesions of the uterine cervix

Invasive cervical cancer is second most common female cancer worldwide with about 493, 000 new cases per year. About 273, 000 women die from cervical cancer each year, 85% of which take place in developing countries. Cervical cancer has a slow progress, from pre-invasive cervical intraepithelial neoplasia (CIN) to invasive phases, meaning that the disease can be diagnosed while in the phase of pre-invasive lesion, and treated successfully thanks to the regular screening of asymptomatic women (the Pap smear). The authors review new possibilities of early detection of cervical cancer with emphasis on colposcopy. The role of colposcopy is discussed among possibilities of early diagnosis. The authors discuss additional diagnostic procedures for preinvasive lesions of the uterine cervix like DNA cytometry, (flow cytometry). This method can point to dysplasia which can progress to severe stages, such as HSIL (High grade Squamous Intraepithelial Lesion). If the level of chromosomal disturbance is higher (aneuploidy), it is more probable that HSIL will develop. Laser screening of cells extracted with modern cytologic screening LBC (Liquid Base Cytology) enables us to automatically measure ploidy (chromosome regularity, or irregularity) and PCR provides analysis of HPV types. These methods are recommended for a routine check-up of borderline cervical lesions in order to anticipate ones likely to regress or progress.

cervical cancer ; prevention ; colposcopy ; cervical iIntraepithelial neoplasia ; CIN

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Podaci o izdanju

33 (4)

2009.

1431-1436

objavljeno

0350-6134

Povezanost rada

Kliničke medicinske znanosti

Poveznice
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