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Tyrosine phosphorylation in Bacteria - puzzle of Streptomyces signalling

Tyrosine phosphorylation in bacteria is still the puzzle of Streptomyces signalling. While two-component signalling systems based on histidine kinase cascades are crucial in bacteria, protein phosphorylation on tyrosine, well-known in eukaryotes, was only recently recognised in prokaryotes. Our group have discovered such phosphorylation on Streptomyces single-stranded DNA binding protein (SSB) and I will discuss that such SSB modification is likely to be an important new regulatory mechanism in these organisms, with implications for differentiation and secondary metabolite formation.

two component signaling system; SSB; tyrosine kinase

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