Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Collection and composition of autologous paripheral blood stem cells graft in patients with acute myeloid leukemia : influence on hematopoietic recovery and outcome (CROSBI ID 162661)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Raos, Mirela ; Nemet, Damir ; Bojanić, Ines ; Sertić, Dubravka ; Batinić, Drago ; Dušak, Vesna ; Mazić, Sanja ; Dubravčić, Klara ; Serventi-Seiwerth Ranka ; Mrsić, Mirando et al. Collection and composition of autologous paripheral blood stem cells graft in patients with acute myeloid leukemia : influence on hematopoietic recovery and outcome // Collegium antropologicum, 34 (2010), 1; 105-115

Podaci o odgovornosti

Raos, Mirela ; Nemet, Damir ; Bojanić, Ines ; Sertić, Dubravka ; Batinić, Drago ; Dušak, Vesna ; Mazić, Sanja ; Dubravčić, Klara ; Serventi-Seiwerth Ranka ; Mrsić, Mirando ; Golubić-Ćepulić, Branka ; Labar, Boris

engleski

Collection and composition of autologous paripheral blood stem cells graft in patients with acute myeloid leukemia : influence on hematopoietic recovery and outcome

Hematopoietic stem cell (HSC) transplantation is a standard approach in the treatment of hematological malignant diseases. For the last 15 years the main source of cells for trasplantation have been peripheral blood stem cells (PBSC). With the availability of hematopoietic growth factors and understanding the advantages of treatment with PBSC, the application of bone marrow (BM) was supplanted. The aim of this survey was to explore the success of PBSC collection, the factors which influence the success of PBSC collection, the composition and the quality of graft and their infuence on hematopoietic recovery and outcome after transplantation in patients with acute myeloid leukemia (AML). PBSC were collected by the method of leukapheresis after applying a combination of chemotherapy and growth factors or only growth factors. The quality of graft was determined with the clonogenic progenitor cell assay and with the flow citometry analysis. Of the total 134 patients with AML, who were submitted to HSC mobilization, the collection was successful in 78 (58.2%) patients. The collection was more successful after the first than after the second attempt of HSC mobilization (49% vs. 11%). The criteria for effective mobilization were the number of leukocytes >3´109/L and the concentration of CD34+ cells >20´103/mL in the peripheral blood on the first day of leukapheresis. The number of CD34+ cells infused had the strongest impact on hematopoietic recovery. We noted significantly faster hematological recovery of neutrophils and platelets, fewer number of transfused units of red blood cells and platelets, shorter duration of the tranfusion support, shorter treatment with intravenous antibiotic therapy and shorter hospitalization after PBSC compared to BM transplantation. These advantages could provide their standard application in the treatment of patients with AML.

auotologous peripheral blood stem cells ; acute leukemia ; hematopoietic recovery

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

34 (1)

2010.

105-115

objavljeno

0350-6134

Povezanost rada

Informacijske i komunikacijske znanosti, Kineziologija, Kliničke medicinske znanosti

Poveznice
Indeksiranost