engleski

Clinical evaluation and 5-year follow up of 673 patients with peptic ulcers, functional dyspepsia, and gastroesophageal reflux disease: influence of H. pylori infection and successful eradication

Aim: We followed 673 patients with peptic ulcers (gastric-GU and duodenal-DU), non-ulcer dyspepsia-NUD and gastroesophageal reflux disease-GERD and calculated influence of HP infection and eradication of this infection on clinical symptoms (epigastric pain, heartburn, non-specific symptoms). Patients: We followed 378 peptic ulcers patients (GU-182, DU-196), 173 with NUD and 122 with GERD et lest 5 years (endoscopy with 4 gastric biopsy, culture and serology on every control). Frequencies of symptoms were calculated on the beginning and on the end of follow-up. Results: On first examination 79, 7 GU, 85, 2 DU, 72, 3 NUD, and 69, 7 GERB patients were HP positive. The frequency of all symptoms was statistically equal among HP-positive and HP-negative patients. After 5 years statistically more ulcer-patients (87, 4% GU, 82, 7% DU), then others (76, 3% NUD and 74, 6%GERB) were eradicated. Epigastric pain was less frequent in both ulcers and NUD patients regardless of eradication, but more frequent in both (eradicated and non-eradicated) GERB patients . Heartburn was slightly more frequent in both ulcers and significantly in NUD patient, but less frequent in GERB patients, especially HP-positive (71, 0% and 81, 3%) in comparation with 100% on first examination. Conclusion. After 5 years, with 1-4 cycles of eradication therapy, statistically more ulcers than NUD and GERB patients were eradicated. Ulcers and NUD patients had less frequent epigastric pain, but GERB patients had pain more frequent, especially HP-positive. Heartburn was slightly more frequent in both ulcers and significantly in NUD patient, but less frequent in GERB patients, especially HP-positive.

Helicobacter pylori; eradication therapy success

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