Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Lower TLR8 expression restores in the convalescent phase upon acute RSV infection in infants (CROSBI ID 562044)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Bendelja, Krešo ; Vojvoda, Valerija ; Baće, Ana ; Turkalj, Mirjana ; Gagro, Alenka ; Mlinarić-Galinović, Gordana ; Rabatić, Sabina Lower TLR8 expression restores in the convalescent phase upon acute RSV infection in infants // Book of abstracts / Rabatić, Sabina (ur.). Zagreb, 2009. str. 16-16

Podaci o odgovornosti

Bendelja, Krešo ; Vojvoda, Valerija ; Baće, Ana ; Turkalj, Mirjana ; Gagro, Alenka ; Mlinarić-Galinović, Gordana ; Rabatić, Sabina

engleski

Lower TLR8 expression restores in the convalescent phase upon acute RSV infection in infants

Infants are particularly sensitive to different viral infections with emphasized detrimental effect of respiratory syncytial virus (RSV) inducing lower respiratory tract infections that could be related to inadequate antiviral immunity. Toll-like receptors (TLRs) are part of the innate immunity able to activate immune defense upon pathogen challenge. TLR3 and TLR8 recognize viral RNA and initiate cascade of antiviral mechanisms and develop specific immune reaction. Inadequate TLR3 and TLR8 engagement in innate immunity responses could result in inability to control RSV replication, to induce anti-viral cytokines and development of specific anti-RSV immune response. In our study specific monoclonal antibodies against human TLR3 and TLR8 were used to determine expression in monocytes from healthy infants, RSV-infected infants during acute infection and convalescent phase. Functional status of TLR's in monocytes was assessed by intracellular TNF-alpha and IL-10 staining upon TLR-specific stimulation. RSV-infected infants had lower percentages of TLR3 and TLR8 positive monocytes than healthy controls and RSV-infected infants in convalescent phase. Lower TLR8 expression during acute RSV-infection was accompanied by the lower TNF-alpha synthesis that substantially increased in the convalescent phase, whereas IL-10 synthesis was higher in acute phase and decreased post-infection. In conclusion, lower expression of TLR8 in acute RSV-infected infants could indicate insufficient participation of innate immune mechanisms that are responsible for the control of RSV replication and generation an effective immune response. Moreover, lower TLR8 expression might represent a specific RSV-mediated mechanism circumventing effective antiviral immune response.

RSV; toll like receptor; TLR3; TLR7; TLR8

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

16-16.

2009.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Book of abstracts

Rabatić, Sabina

Zagreb:

Podaci o skupu

Annual meeting of the Croatian Immunological Society 2009

predavanje

01.10.2009-04.10.2009

Starigrad, Hrvatska

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti