engleski

Propofol abolished the phrenic long-term facilitation in rats

The aim was to investigate the effect of propofol anesthesia on the phrenic long-term facilitation (LTF) in rats. We hypothesized that there would be a significant attenuation of LTF during propofol compared with urethane anesthesia. Fourteen adult, male, anesthetized, vagotomized, paralyzed, and mechanically ventilated Sprague-Dawley rats (7 per group), were exposed to the acute intermittent hypoxia (AIH) protocol. Peak phrenic nerve amplitude (PNA), burst frequency (f), and breathing rhythm parameters (Ti, Te, Ttot) were analyzed during the first hypoxia (TH1), as well as at 15 (T15), 30 (T30), and 60 minutes (T60) after the final hypoxic episode, and compared to the baseline values. In propofol-anesthetized rats no significant changes of PNA were recorded after the last hypoxic episode, i.e. no LTF was induced. There was a significant increase of PNA (59.4 ± 6.6%, p<0.001) in control group at T60. AIH did not elicit significant changes in f, Ti, Te, Ttot in either group at T15, T30, and T60. The phrenic LTF, elicited by AIH, was induced in the urethane-anesthetized rats. On the contrary, phrenic LTF was abolished in the propofol-anesthetized rats.

respiration; phrenic nerve; intermittent hypoxia; propofol; rats; neuronal plasticity

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