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izvor podataka: crosbi !

Duplikacija kromosoma kao posljedica pop-out rekombinacije (CROSBI ID 358710)

Ocjenski rad | sveučilišni preddiplomski završni rad

Žunar, Bojan Duplikacija kromosoma kao posljedica pop-out rekombinacije / Svetec, Ivan-Krešimir (mentor); Lisnić, Berislav ; Štafa, Anamarija ; Miklenić, Marina (neposredni voditelj). Zagreb, Prehrambeno-biotehnološki fakultet, . 2009

Podaci o odgovornosti

Žunar, Bojan

Svetec, Ivan-Krešimir

Lisnić, Berislav ; Štafa, Anamarija ; Miklenić, Marina

hrvatski

Duplikacija kromosoma kao posljedica pop-out rekombinacije

As yeast Saccharomyces cerevisiae is of considerable importance in industry, and in science, it is often chosen as the subject of experiments. Today there is a substantial number of research on evolution-related processes shaping the genome of this eukaryote. Although many facts are now revealed, much is still unknown, such as molecular mechanisms of these processes. Therefore, the aim of this paper was to investigate the possibility of an illegitimate integration of an endogenous DNA formed during a pop-out recombination event between two repeated sequences, in accordance with the SSA model (single strand annealing model). As we were unable to detect this kind of event, we can conclude that its rate is less than 10-8. Our results also indicate that pop-out recombination can initiate chromosome duplication, which is significant from evolutionary viewpoint. Also, the experimental system developed for this research can be utilized in the construction of disomic yeast strains.

Saccharomyces cerevisiae; pop-out rekombinacija; SSA-model; evolucija genoma; duplikacija kromosoma

nije evidentirano

engleski

Chromosome duplication as a result of pop-out recombination

nije evidentirano

Saccharomyces cerevisiae; pop-out recombination; SSA model; genome evolution; chromosome duplication

nije evidentirano

Podaci o izdanju

30

10.07.2009.

obranjeno

Podaci o ustanovi koja je dodijelila akademski stupanj

Prehrambeno-biotehnološki fakultet

Zagreb

Povezanost rada

Biotehnologija