engleski

Influence of the inherited glucose-6-phosphate dehydrogenase deficiency on the appearance and the course of neonatal hyperbilirubinemia

Aim: The aim of this study was to determine the influence of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency on the appearance and the course of neonatal hyperbilirubinemia in Central Dalmatia region. Methods: The florescent spot test was used in the retrospective study to screen blood samples of 513 male children which had neonatal hyperbilirubinemia higher than 240µmol/L. Florescence reading was performed at the beginning and at the 5th, 10th and 20th minutes of incubation and was classified into three groups: bright florescence, weak florescence and no florescence. Samples with no florescence and weak florescence reading in 5th minute were quantitatively measured using spectrophotometric method. Results: Bright florescence in 5th, 10th, and 20th minute were present in 461 samples (90%). The rest 52 samples (10%) were quantitatively measured using spectrophotometric method and in 32 of them there were normal G-6-PD activity but 20 samples (3, 9%) were G-6-PD deficient. The average of hospitalization of the children with newborn jaundice and G-6-PD deficiency were 15, 8 days, and 9 days for the same children with normal G-6-PD activity. Conclusion: Prevalence rate of G-6-PD deficiency among newborns in Central Dalmatia region is significantly higher (p< 0, 001) compared to the prevalence rate among men in Central Dalmatia region (0, 75% in males). We can also conclude that G-6PD deficiency has an influence on a course of newborn jaundice. The children with newborn jaundice and G-6-PD deficiency have had a significantly longer hospitalization then children with neonatal hyperbilirubinemia and normal G-6-PD.

G-6-PD deficiency; neonatal hyperbilirubinemia; florescent spot test; Central Dalmatia

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