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A fluid-structure interaction study of biofilm detachment

During the biofilm development process, bacterial cells may detach from the biofilm into the surrounding fluid. The key question in relation to detachment from bacterial biofilm is the mechanical response to hydrodynamic forces. In this study, a Finite Volume Method (FVM) based Fluid-Structure Interaction (FSI) solver in OpenFOAM package has been developed to model the biofilm response to flow [1]. Dynamic interaction was simulated between an incompressible Newtonian fluid and a bacterial biofilm described as a linear viscoelastic solid. Viscoelastic response of the biofilm was represented by the hereditary integral form of constitutive relation [2] while tensile relaxation modulus was expressed by the Generalised Maxwell Model (GMM) in the form of Prony series (a discrete retardation spectrum). GMM was obtained from the rheometry creep experimental data using a three-step method proposed by Dooling et al. [3]. The creep curves were all viscoelastic in nature and approximated by a linear viscoelastic model represented by Generalised Voigt Model (GVM). Elastic shear modulus (G), obtained from the three-step method, ranged from 583Pa to 1368Pa which were similar to the previous rheometry studies. In this two-dimensional model, biofilm was considered as semi-hemispherical shape (thickness of 100μm and width of 346μm) attached to the center of the bottom boundary of the square cross-section flow cell. Fluid flow through the flow cell was in laminar regime. Simulation results predicted the potential site for biofilm detachment subjected to increasing fluid flow rate through the flow cell.

biofilm; viscoelasticity; fluid-structure interaction; Finite Volume Method

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