Aseptic Meningitis, Sensorineural Hearing Loss and Vestibulopathy Induced by Simultaneous Use of Ranitidine, Ibuprofen and Ciprofloxacin (CROSBI ID 163682)
Prilog u časopisu | prethodno priopćenje
Podaci o odgovornosti
Sepčić, Juraj ; Bučuk, Mira ; Perković, Olivio ; Šepić-Grahovac, Dubravka ; Trošelj-Vukić, Biserka ; Poljak, Ivica ; Crnić-Martinvić, Marija ; Turel, Iztok ; Ristić, Smiljana ; Sepčić, Kristina
engleski
Aseptic Meningitis, Sensorineural Hearing Loss and Vestibulopathy Induced by Simultaneous Use of Ranitidine, Ibuprofen and Ciprofloxacin
We report clinically rare and serious adverse reactions that occurred after the co administration of ranitidine, ibuprofen and ciprofloxacin: completely reversible aseptic meningitis and irreversible bilateral sensorineural hearing loss, tinnitus, and vestibulopathy. Recurrent urinary inflammations treated with antibacterial, classic familial migraine, and allergy to trimethoprim-sulfamethoxazole and chromium were favourable predisposing factors for the adverse event in this patient. A close chronological relation between administration of drugs (especially ibuprofen) and adverse reactions was noted. No evidence of infection ant/or autoimmune disease was found. The mechanism of these serious events may be explained as a hypersensitive reaction affecting the meninges and, partially, cochlea.
ranitidine; ibuprofen; ciprofloxacin; drug interactions; aseptic meningitis; deafness
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
Povezanost rada
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Farmacija