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New loci associated with kidney function and chronic kidney disease (CROSBI ID 163902)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Köttgen, A. ; Pattaro, C. ; Böger, C.A. ; Fuchsberger, C. ; Olden, M. ; Glazer, N.L. ; Parsa, A. ; Gao, X. ; Yang, Q. ; Smith, A.V. et al. New loci associated with kidney function and chronic kidney disease // Nature genetics, 42 (2010), 5; 376-384. doi: 10.1038/ng.568

Podaci o odgovornosti

Köttgen, A. ; Pattaro, C. ; Böger, C.A. ; Fuchsberger, C. ; Olden, M. ; Glazer, N.L. ; Parsa, A. ; Gao, X. ; Yang, Q. ; Smith, A.V. ; O'Connell, J.R. ; Li, M. ; Schmidt, H. ; Tanaka, T. ; Isaacs, A. ; Ketkar, S. ; Hwang, S.J. ; Johnson, A.D. ; Dehghan, A. ; Teumer, A. ; Paré, G. ; Atkinson, E.J. ; Zeller, T. ; Lohman, K. ; Cornelis, M.C. ; Probst-Hensch, N.M, ; Kronenberg, F. ; Tönjes, A. ; Hayward, C. ; Aspelund, T. ; Eiriksdottir, G. ; Launer, L.J. ; Harris, T.B. ; Rampersaud, E. ; Mitchell, B.D. ; Arking, D.E. ; Boerwinkle, E. ; Struchalin, M. ; Cavalieri, M. ; Singleton, A. ; Giallauria, F. ; Metter, J. ; de Boer, I.H. ; Haritunians, T. ; Lumley, T. ; Siscovick, D. ; Psaty, B.M. ; Zillikens, M.C. ; Oostra, B.A. ; Feitosa, M. ; Province, M. ; de Andrade, M. ; Turner, S.T. ; Schillert, A. ; Ziegler, A. ; Wild, P.S. ; Schnabel, R.B. ; Wilde, S. ; Munzel, T.F. ; Leak, T.S. ; Illig, T. ; Klopp, N. ; Meisinger, C. ; Wichmann, H.E. ; Koenig, W. ; Zgaga, Lina ; Zemunik, Tatijana ; Kolčić, Ivana ; Minelli, C. ; Hu, F.B. ; Johansson, A. ; Igl, W. ; Zaboli, G. ; Wild, S.H. ; Wright, A.F. ; Campbell, H. ; Ellinghaus, D. ; Schreiber, S. ; Aulchenko, Y.S. ; Felix, J.F. ; Rivadeneira, F. ; Uitterlinden, A.G. ; Hofman, A. ; Imboden, M. ; Nitsch, D. ; Brandstätter, A. ; Kollerits, B. ; Kedenko, L. ; Mägi, R. ; Stumvoll, M. ; Kovacs, P. ; Boban, M. ; Campbell, S. ; Endlich, K. ; Völzke, H. ; Kroemer, H.K. ; Nauck, M. ; Völker, U. ; Polašek, Ozren ; Vitart, V. ; Badola, S. ; Parker, A.N. ; Ridker, P.M. ; Kardia, S.L. ; Blankenberg, S. ; Liu, Y. ; Curhan, G.C. ; Franke, A. ; Rochat, T. ; Paulweber, B. ; Prokopenko, I. ; Wang, W. ; Gudnason, V. ; Shuldiner, A.R. ; Coresh, J. ; Schmidt, R. ; Ferrucci, L. ; Shlipak, M.G. ; van Duijn, C.M. ; Borecki, I. ; Krämer, B.K. ; Rudan, Igor ; Gyllensten, U. ; Wilson, J.F. ; Witteman, J.C. ; Pramstaller, P.P. ; Rettig, R. ; Hastie, N. ; Chasman, D.I. ; Kao, W.H. ; Heid, I.M. ; Fox, C.S.

engleski

New loci associated with kidney function and chronic kidney disease

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta- analysis of genome-wide association data in 67, 093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2) ; n = 5, 807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22, 982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

chronic kidney disease; loci; SNP

nije evidentirano

nije evidentirano

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nije evidentirano

nije evidentirano

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Podaci o izdanju

42 (5)

2010.

376-384

objavljeno

1061-4036

10.1038/ng.568

Povezanost rada

Javno zdravstvo i zdravstvena zaštita

Poveznice
Indeksiranost