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Meta-analysis and imputation refines the association of 15q25 with smoking quantity (CROSBI ID 163930)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Liu, Jason Z. ; ... ; Polašek, Ozren ; Zgaga, Lina ; ... ; Rudan, Igor ; ... ; Kolčić, Ivana ; ... ; Marchini, Jonathan Meta-analysis and imputation refines the association of 15q25 with smoking quantity // Nature genetics, 42 (2010), 5; 436-440. doi: 10.1038/ng.572

Podaci o odgovornosti

Liu, Jason Z. ; ... ; Polašek, Ozren ; Zgaga, Lina ; ... ; Rudan, Igor ; ... ; Kolčić, Ivana ; ... ; Marchini, Jonathan

engleski

Meta-analysis and imputation refines the association of 15q25 with smoking quantity

Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41, 150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.

genome-wide association study; smoking initiation; smoking quantity

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Podaci o izdanju

42 (5)

2010.

436-440

objavljeno

1061-4036

10.1038/ng.572

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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