Interaction of DBTAA derivatives with DNA / RNA and antiproliferative effects on human cell lines (CROSBI ID 563355)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Radić Stojković, Marijana ; Piantanida, Ivo ; Kralj, Marijeta ; Marjanović, Marko ; Pawlica, Dariusz ; Eilmes, Julita
engleski
Interaction of DBTAA derivatives with DNA / RNA and antiproliferative effects on human cell lines
Previous reports from our laboratory have described the binding properties of a series of dibenzotetraaza[14]annulenes (DBTAA) derivatives 1, 2 (Scheme 1). Scheme 1. Previously studied dibenzotetraaza[14]annulenes (DBTAA) derivatives 1, 2. We now report the binding activity of a new series of DBTAA derivatives studied by electronic absorption, circular dichroism and fluorescence spectroscopy, as well as by thermal melting experiments. The intensive hypochromic and batochromic effect in UV/Vis titrations, high affinity, strong thermal stabilisation of both, DNA and RNA, similar ICD spectra upon DNA and RNA addition strongly support the intercalation between polynucleotide base pairs as dominant mode of binding for all studied compounds. Antiproliferative effect of studied compounds on human tumor and normal cell lines was consistent with the strength of observed interactions with DNA/RNA, thus implying that interactions with cellular DNA and/or RNA are the most likely targets within the cell.
DBTAA derivatives; DNA/RNA polynucleotides; intercalation; antiproliferative effect
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
99-99.
2009.
objavljeno
Podaci o matičnoj publikaciji
XXI. Hrvatski skup kemičara i kemijskih inženjera – Knjiga sažetaka
Novak, Predrag ; Pičuljan, Katarina ; Smolec, Sonja
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI)
978-953-6894-38-3
Podaci o skupu
XXI. Hrvatski skup kemičara i kemijskih inženjera
poster
19.07.2009-22.07.2009
Trogir, Hrvatska