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A case of chronic and extensive dermatomycosis in a diabetic patient (CROSBI ID 563500)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Peternel, Sandra ; Simonić, Edita ; Brajac, Ines ; Kaštelan, Marija A case of chronic and extensive dermatomycosis in a diabetic patient // 7th EADV Spring Symposium Abstracts on CD-ROM. 2010. str. P198-x

Podaci o odgovornosti

Peternel, Sandra ; Simonić, Edita ; Brajac, Ines ; Kaštelan, Marija

engleski

A case of chronic and extensive dermatomycosis in a diabetic patient

Aims: We report a case of an unusually widespread and chronic mixed-species dermatomycosis occurring in a diabetic patient. Methods: Diagnosis of dermatomycosis was made by detailed clinical examination of skin lesions, Wood light examination, direct microscopic evaluation of KOH preparations from skin scrapings and identification of fungal species grown in culture on Sabouraud’s dextrose agar. Repeated cultures from multiple sites were performed. A 12-week treatment consisted of topical and systemic terbinafine (250 mg/kg). Results (Case report): A 58-year-old man with 12-year history of diabetes presented with extensive pruritic skin changes. The lesions involved per continuitatem the whole trunk, groin, gluteal regions and lower extremities. The involved skin was diffusely erythematous and lichenified with fine scales and numerous excoriations, sharply demarcated toward the uninvolved skin, with raised borders and no signs of central regression. The patient also had thickened and discoloured toenails and discrete erosions between toes. Wood light examination of lesional skin was negative. Direct microscopic examination of scales obtained from the borders of skin lesions, groin area, toenails and interdigital web spaces revealed numerous mycelial elements. Cultures of skin scrapings yielded Aspergillus fumigatus from the borders of skin lesions and inguinal region, Candida albicans from toenails and both Aspergillus fumigatus and Trichophyton rubrum from interdigital web spaces. A 12-week treatment with oral terbinafine resulted in complete mycological and clinical clearance. Slight residual hyperpigmentation was visible at sites of previously affected skin and strong regrowth of hair was evident at patient’s trunk. Conclusions: Fungi represent a diverse group of pathogens with opportunism being a common ground in the pathogenesis. We report this case for its unusual clinical appearance, chronicity and the presence of multiple causative pathogens, all of which might have been favoured by compromised natural defences due to diabetes mellitus.

dermatomycosis; diabetes mellitus; terbinafine

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Podaci o prilogu

P198-x.

2010.

objavljeno

Podaci o matičnoj publikaciji

7th EADV Spring Symposium Abstracts on CD-ROM

Podaci o skupu

7th EADV Spring Symposium

poster

13.05.2010-16.05.2010

Cavtat, Hrvatska

Povezanost rada

Kliničke medicinske znanosti